Creamy Cajun Chicken Twisted Pasta with Mozzarella Alfredo

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Rich, creamy, and packed with bold flavor, this Creamy Cajun Chicken Twisted Pasta with Mozzarella Alfredo is the perfect comfort meal when you’re craving something indulgent yet exciting. Tender rotini pasta is coated in a smooth and cheesy mozzarella Alfredo sauce, paired with crispy, seasoned Cajun chicken for that spicy kick. Every bite is a balance of creamy, cheesy goodness and savory heat.

Whether you’re cooking for your family on a busy weeknight or serving guests something a little fancy, this dish delivers both on taste and presentation. The golden crust on the chicken adds a satisfying crunch, while the creamy Alfredo clings beautifully to each twist of pasta. This is comfort food with a flavorful twist.

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Preparation Phase & Tools to Use

To get that picture-perfect Cajun chicken and silky Alfredo pasta, you’ll need just a few key kitchen tools:

• Cast Iron Skillet or Nonstick Frying Pan: Ideal for getting a perfect golden-brown crust on your Cajun chicken without sticking or burning.
• Large Pot: You’ll need a sturdy pot to boil your rotini pasta evenly and quickly.
• Colander: Helps drain the pasta efficiently without breaking the twists.
• Saucepan: Essential for building the mozzarella Alfredo sauce—gentle heat control is key for smooth, non-gritty cheese sauce.
• Tongs and Whisk: Tongs for flipping the chicken and whisk for ensuring your Alfredo stays lump-free.

The right tools do more than make cooking easier—they help create textures and layers that really elevate the final dish.

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Ingredients for the Creamy Cajun Chicken Twisted Pasta with Mozzarella Alfredo

• Rotini Pasta: Its twisty shape holds onto the rich Alfredo sauce perfectly, delivering maximum flavor in each bite.
• Boneless Skinless Chicken Breasts: Lean and protein-packed, they provide a crispy and flavorful contrast to the creamy pasta.
• Cajun Seasoning: Adds a spicy, smoky depth that elevates the whole dish.
• Olive Oil: Helps the Cajun seasoning stick and crisps up the chicken in the pan.
• Mozzarella Cheese (Shredded): Melts into the Alfredo sauce for an ultra-creamy, gooey texture.
• Heavy Cream: The base of the Alfredo sauce, making it thick and luscious.
• Parmesan Cheese (Grated): Adds saltiness and sharp depth to balance the creaminess.
• Butter: Enriches the sauce and helps emulsify all the cheese together.
• Garlic (Minced): Provides aromatic depth and a mild bite.
• Fresh Parsley (Chopped): Optional, but adds a pop of color and freshness to the final plate.

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How To Make the Creamy Cajun Chicken Twisted Pasta with Mozzarella Alfredo

Step 1: Season and Sear the Chicken

Rub Cajun seasoning generously on both sides of the chicken breasts. Heat olive oil in a skillet over medium-high heat, then cook the chicken for about 4–5 minutes per side until golden and cooked through. Remove, rest, then slice.

Step 2: Boil the Pasta

Cook rotini in salted boiling water according to package instructions until al dente. Drain and set aside.

Step 3: Make the Mozzarella Alfredo Sauce

In a saucepan, melt butter over medium heat. Add minced garlic and sauté for 30 seconds. Stir in heavy cream and bring to a gentle simmer. Gradually whisk in mozzarella and Parmesan cheese until fully melted and smooth.

Step 4: Combine Pasta with Sauce

Add the drained rotini into the sauce and toss until evenly coated. Let it simmer for a minute so the pasta absorbs some of the sauce.

Step 5: Serve with Cajun Chicken

Plate the creamy pasta and top with the sliced Cajun chicken. Garnish with fresh parsley for a vibrant finish.

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Serving and Storing This Creamy Cajun Chicken Pasta

Serve this dish immediately while the sauce is still velvety and the chicken is crisp. A side of garlic bread or a light salad pairs perfectly to balance the richness.

If you have leftovers, store them in an airtight container in the refrigerator for up to 3 days. To reheat, gently warm on the stovetop with a splash of cream or milk to loosen the sauce. Avoid microwaving the chicken too long, as it may lose its crispy texture.

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Frequently Asked Questions

Can I use a different type of pasta?

Absolutely! Penne, fettuccine, or even bowtie pasta work well. Just choose a pasta that holds onto sauce effectively.

What if I don’t have Cajun seasoning?

You can make your own using paprika, garlic powder, onion powder, thyme, oregano, black pepper, and cayenne. Or swap with Creole seasoning for a similar kick.

Can I use milk instead of heavy cream?

Heavy cream gives the Alfredo sauce its richness, but you can use whole milk with a bit of flour or cream cheese for thickening.

Is there a vegetarian version of this dish?

Yes! Skip the chicken and use roasted veggies like bell peppers, zucchini, and mushrooms seasoned with Cajun spice.

Can I make this ahead of time?

You can prep the chicken and Alfredo sauce ahead, then cook pasta and assemble fresh when serving for best texture.

What can I do if my Alfredo sauce turns grainy?

Use low heat and whisk continuously when adding cheese. Graininess usually comes from overheating or adding cheese too quickly.

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Want More Pasta Ideas with a Twist?

If you loved this Creamy Cajun Chicken Twisted Pasta with Mozzarella Alfredo, here are more pasta creations to explore:

• Cheesy Garlic Chicken and Broccoli Pasta for a cozy, veggie-packed dish.
• Creamy Garlic Butter Chicken Rotini in Parmesan Sauce if you adore creamy richness.
• Sweet Spicy Garlic Honey BBQ Chicken Pasta for that sweet heat combo.
• One Skillet Spicy Garlic Butter Parmesan Steak Pasta if you’re craving steak instead of chicken.
• One Pot Chicken Parmesan Mac & Cheese for a baked comfort classic.

Looking for even more dinner inspiration? Follow me on Pinterest where I share daily recipes: Life With Olivia on Pinterest.

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And let me know in the comments how yours turned out. Did you spice it up even more? Add a different cheese? Maybe toss in some veggies?

I love seeing how you make these recipes your own. Drop your tweaks or questions below—we’re all here to cook smarter and eat better.

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