Creamy Cajun Chicken Rotini with Mozzarella Alfredo Sauce

WANT TO SAVE THIS RECIPE?

Looking to spice up your dinner plans with a soul-warming, flavor-packed dish? Creamy Cajun Chicken Rotini with Mozzarella Alfredo Sauce is your answer. This irresistible combination of crispy, seasoned chicken and velvety, cheesy pasta sauce creates a comforting, indulgent meal that brings Southern flair to your table. The Cajun spices add just the right amount of heat, while the mozzarella Alfredo balances it out with a creamy richness.

Perfect for weeknight dinners or special weekend feasts, this recipe is the kind that turns simple ingredients into a standout favorite. The golden-crusted chicken is juicy and flavorful, and when paired with rotini that holds the sauce in every twist, it becomes a bite of pure satisfaction. If you’re a fan of creamy pasta and bold flavor, you’ll be making this on repeat.

---

Preparation Phase & Tools to Use

To make the best Creamy Cajun Chicken Rotini, having the right tools on hand is key:

• Cast Iron Skillet or Nonstick Pan: For perfectly seared chicken that locks in flavor.
• Large Pot: Essential for boiling rotini without overcrowding and sticking.
• Colander: To drain the pasta efficiently without losing any noodles.
• Wooden Spoon or Silicone Spatula: Ideal for stirring sauces without scratching your pan.
• Whisk: Helps blend the Alfredo sauce smoothly, eliminating clumps.

Investing in these tools ensures each element of your dish turns out deliciously and saves you time in the kitchen.

---

Ingredients for the Creamy Cajun Chicken Rotini with Mozzarella Alfredo Sauce

• Rotini Pasta: Its spirals hold onto the creamy Alfredo sauce perfectly.
• Boneless Chicken Breast or Thighs: Juicy, tender meat that pairs beautifully with Cajun spices.
• Cajun Seasoning: Adds smoky heat and robust flavor.
• Garlic Powder and Onion Powder: Enhances the depth of the seasoning on the chicken.
• Butter: For sautéing and building a flavorful Alfredo base.
• Heavy Cream: Provides the rich, velvety foundation for the sauce.
• Mozzarella Cheese: Melts into the sauce to create that signature creamy, cheesy texture.
• Parmesan Cheese: Brings a nutty sharpness and depth to the Alfredo.
• Fresh Parsley: A pop of color and freshness to finish the dish.
• Salt and Pepper: For balancing and enhancing the flavors.

---

How To Make the Creamy Cajun Chicken Rotini with Mozzarella Alfredo Sauce

Step 1: Season and Sear the Chicken

Generously season your chicken with Cajun seasoning, garlic powder, onion powder, salt, and pepper. Heat your skillet with a bit of butter or oil and sear the chicken until golden brown and cooked through. Slice and set aside.

Step 2: Cook the Rotini

In a large pot of salted boiling water, cook the rotini according to package directions until al dente. Drain and set aside.

Step 3: Make the Mozzarella Alfredo Sauce

In the same skillet used for the chicken, melt butter and add heavy cream. Whisk until warm and slightly thickened. Stir in mozzarella and Parmesan cheese until melted and creamy.

Step 4: Combine Pasta and Sauce

Toss the cooked rotini into the Alfredo sauce. Stir until every twist of pasta is coated in cheesy goodness.

Step 5: Add Chicken and Garnish

Top the creamy rotini with sliced Cajun chicken. Sprinkle with fresh parsley and an extra pinch of Cajun seasoning if desired.

---

Serving and Storing the Creamy Cajun Chicken Rotini

This dish is best served hot, fresh off the stove with an extra sprinkle of Parmesan or Cajun spice for a flavor punch. Pair it with crusty garlic bread or a crisp green salad to round out the meal.

To store leftovers, place the pasta and chicken in an airtight container and refrigerate for up to 3 days. Reheat gently on the stove or microwave with a splash of cream or milk to revive the sauce’s creaminess. Avoid freezing, as the dairy sauce can separate and change texture.

---

Frequently Asked Questions

How spicy is this dish?

The spice level is moderate thanks to the Cajun seasoning. You can easily adjust the heat by using more or less seasoning based on your preference.

Can I use a different pasta?

Yes! While rotini is great for holding onto sauce, penne or farfalle also work well in this recipe.

Can I make this ahead of time?

You can cook the chicken and prepare the Alfredo sauce ahead, then just boil the pasta and reheat the sauce when ready to serve.

What can I substitute for heavy cream?

Half-and-half or whole milk with a bit of cream cheese can work in a pinch, though it will be slightly less rich.

Is this recipe gluten-free?

Not as written, but you can substitute gluten-free rotini and ensure your Cajun seasoning is certified gluten-free.

Can I bake this dish?

Yes! After combining everything, transfer to a baking dish, sprinkle more cheese on top, and bake at 375°F for 10-15 minutes until bubbly.

---

Want More Chicken Pasta Ideas?

If you love this Creamy Cajun Chicken Rotini, check out these other comforting favorites:

• One-Pot Chicken Parmesan Mac & Cheese
• Sweet & Spicy Garlic Honey BBQ Chicken Pasta
• Cheesy Garlic Chicken and Broccoli Pasta
• Creamy Garlic Butter Chicken Rotini in Parmesan Sauce
• Creamy Spicy Buffalo Ranch Pasta

---

Save This Recipe for Later

📌 Save this recipe to your Pinterest dinner board so you can come back to it any time. Follow me on Pinterest for more daily recipes.

And let me know in the comments how yours turned out! Did you add extra heat or mellow it down? Maybe swapped the cheese? I’d love to hear your twist.

Questions welcome too—we’re all here to cook smarter and eat better.

---

Print

WANT TO SAVE THIS RECIPE?