Cheesy Penne and Cajun Chicken in Garlic Parmesan Cream

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Imagine juicy, spiced Cajun chicken paired with rich, creamy garlic parmesan sauce and tender penne pasta that soaks up every drop of flavor. This comforting, crowd-pleasing dish balances bold Cajun heat with a silky, cheesy finish. It’s the kind of meal that turns a regular night into something memorable—without needing hours in the kitchen.

Whether you’re feeding a hungry family or indulging in a cozy date night at home, this recipe brings the perfect combo of spice, cream, and cheese. And the best part? It tastes like a restaurant favorite, but you made it with love at home.

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Preparation Phase & Tools to Use

To prepare this Cheesy Penne and Cajun Chicken in Garlic Parmesan Cream, the right tools will make all the difference. Here’s what you’ll need:

• Cast iron or heavy skillet: Essential for getting that golden, slightly crispy sear on your Cajun chicken. The heat retention adds flavor and texture.
• Large pot: To boil your penne perfectly al dente.
• Tongs or silicone spatula: These help you flip chicken cleanly and stir the sauce without scraping your pans.
• Fine grater or microplane: Freshly grated parmesan melts better and infuses the sauce beautifully.
• Whisk: Crucial for combining the cream sauce ingredients smoothly and evenly.

With these tools ready, your cooking process will be smooth and your results impressive.

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Ingredients for the Cheesy Penne and Cajun Chicken in Garlic Parmesan Cream

• Chicken breasts or thighs: The protein star of the dish. Boneless, skinless pieces work best for quick, even cooking.
• Cajun seasoning: Adds a bold, smoky kick to the chicken, creating contrast with the creamy sauce.
• Penne pasta: Its hollow shape holds onto the sauce so every bite is coated with cheesy goodness.
• Heavy cream: The base of our sauce—rich, indulgent, and the key to a velvety texture.
• Fresh garlic: Adds depth and a warm, savory aroma to the sauce.
• Parmesan cheese: Freshly grated parmesan gives the sauce its signature nutty and salty flavor.
• Butter: Used to sauté garlic and give the sauce a silky mouthfeel.
• Olive oil: Helps achieve that perfect sear on the chicken.
• Salt & black pepper: Balances flavors and enhances each component.
• Fresh parsley (optional): For a bright pop of color and fresh flavor at the end.

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How To Make the Cheesy Penne and Cajun Chicken in Garlic Parmesan Cream

Step 1: Season and Sear the Chicken

Pat the chicken dry and rub both sides generously with Cajun seasoning, salt, and pepper. Heat olive oil in a skillet over medium-high heat. Sear the chicken for 4-6 minutes per side until golden and cooked through. Transfer to a plate to rest.

Step 2: Boil the Pasta

While the chicken cooks, boil a large pot of salted water. Add the penne and cook until al dente, according to package instructions. Drain and set aside.

Step 3: Make the Garlic Parmesan Cream Sauce

In the same skillet, lower the heat to medium. Add butter and minced garlic; sauté until fragrant (about 1 minute). Pour in the heavy cream and stir gently. Let it simmer for 3-4 minutes.

Step 4: Add Parmesan and Combine

Whisk in freshly grated parmesan cheese until melted and smooth. Add the cooked penne to the sauce and stir to coat.

Step 5: Slice and Serve

Slice the Cajun chicken and lay it over the cheesy penne. Garnish with chopped parsley and extra parmesan if desired. Serve hot and enjoy the creamy-spicy magic!

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Best Way to Serve and Store This Creamy Cajun Chicken Pasta

Serve this dish fresh off the stove while it’s warm and saucy. Plate the cheesy penne first, then layer the sliced Cajun chicken on top for a restaurant-style presentation. A sprinkle of fresh parsley or an extra dusting of parmesan is all you need to elevate it.

If you have leftovers, store them in an airtight container in the fridge for up to 3 days. To reheat, add a splash of cream or milk before microwaving or gently warming on the stovetop to bring back the sauce’s creamy texture.

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Frequently Asked Questions

How spicy is Cajun seasoning?

Cajun seasoning typically has a mild to moderate heat, depending on the brand. You can adjust the intensity by adding less or mixing with paprika for a milder blend.

Can I use milk instead of heavy cream?

You can, but it will make the sauce thinner and less rich. Whole milk is better than low-fat, but heavy cream gives the best consistency and flavor.

Can I use a different type of pasta?

Yes! Fettuccine, rotini, or even bowtie pasta all work great. Choose one that holds sauce well.

What can I substitute for parmesan cheese?

Asiago or Romano cheese are good swaps. If you’re dairy-free, try a cashew-based parmesan alternative.

Is this recipe gluten-free?

Not as written, but you can easily use gluten-free pasta and ensure your Cajun seasoning is gluten-free too.

Can I bake this dish after assembling?

Absolutely! Add the cooked pasta and chicken to a baking dish, top with cheese, and bake at 375°F for 15 minutes for a golden, bubbly finish.

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Want More Pasta Ideas with a Twist?

If you love this Cheesy Penne and Cajun Chicken in Garlic Parmesan Cream, you’ll definitely enjoy these other creamy and savory pasta favorites:

• One Skillet Spicy Honey BBQ Sausage Pasta for bold heat and smoky-sweet flavor.
• Creamy Garlic Butter Chicken Rotini in Parmesan Sauce for garlic lovers.
• Beef and Rotini in Garlic Parmesan Sauce if you’re craving a beefy twist on the creamy classic.
• One Pot Chicken Parmesan Mac & Cheese for a kid-friendly, comfort-packed meal.
• Sticky Honey Garlic Steak and Rotini to satisfy your sweet-savory cravings.

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📌 Save this recipe to your Pinterest dinner board so you can come back to it any time: Life With Olivia on Pinterest

And let me know in the comments how yours turned out. Did you add extra garlic? Maybe sprinkle in red pepper flakes? I love seeing how you customize these dishes.

Questions are always welcome—we’re building a delicious community together!

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