If you love bold Cajun flavors and creamy, comforting pasta dishes, this Cheesy Garlic Cajun Chicken Bowtie Pasta in Alfredo Sauce is a must-try. The contrast of juicy, spice-rubbed chicken with rich, velvety Alfredo sauce clinging to bowtie pasta creates a harmony of flavor and texture that’s irresistible.

This dish brings together savory garlic, smoky Cajun spices, and smooth, cheesy Alfredo into one crave-worthy skillet meal. It looks stunning on the plate and delivers cozy comfort with every bite—perfect for weeknight dinners, special occasions, or whenever you want to impress without the stress.

Preparation Phase & Tools to Use

Large Skillet or Cast-Iron Pan: Crucial for searing the Cajun chicken to golden perfection and building flavor in the sauce.

Medium Saucepan: Needed to boil the bowtie pasta until al dente.
Tongs or Spatula: Great for flipping chicken evenly and safely.
Garlic Press or Microplane: Helps achieve fine garlic consistency, which is key for a well-balanced garlic Alfredo.

Whisk: Necessary for emulsifying cheese into the sauce smoothly.
Measuring Spoons and Cups: Ensures consistency in seasoning and sauce texture.

Having these tools prepped keeps the cooking process smooth and lets you focus on layering bold flavor in every element.

Ingredients for the Cheesy Garlic Cajun Chicken Bowtie Pasta

Chicken Breasts: Boneless and skinless chicken breasts are perfect for soaking up the Cajun seasoning and staying juicy when seared.
Cajun Seasoning: Brings smoky heat and bold spice to the chicken—a key flavor profile.
Olive Oil: Used to sear the chicken and infuse the skillet with flavor.

Bowtie Pasta (Farfalle): Holds sauce beautifully with its ridged surface and fun shape.
Garlic: Fresh minced garlic deepens the Alfredo’s flavor and adds aromatic richness.
Butter: Forms the base of the Alfredo, lending richness and smoothness.

Heavy Cream: Gives the sauce its luxurious, velvety texture.
Parmesan Cheese: The backbone of Alfredo sauce, adding sharpness and cheesy depth.
Mozzarella Cheese: Adds melty stretch and balances the Parmesan with milder creaminess.

Italian Seasoning: Enhances the overall herbal profile without overpowering the Cajun spice.
Salt & Pepper: Essential for seasoning both pasta water and the final dish.

How To Make the Cheesy Garlic Cajun Chicken Bowtie Pasta

Step 1: Season and Sear the Chicken

Pat chicken breasts dry, then coat both sides with Cajun seasoning. Heat olive oil in a large skillet over medium-high heat and sear the chicken for 5–7 minutes per side until golden and cooked through. Set aside to rest, then slice.

Step 2: Boil the Bowtie Pasta

In a medium saucepan, boil salted water and cook bowtie pasta until al dente. Reserve ½ cup of pasta water, then drain and set aside.

Step 3: Build the Alfredo Base

In the same skillet, melt butter over medium heat. Add minced garlic and sauté until fragrant. Pour in heavy cream, whisking constantly. Slowly add Parmesan and mozzarella cheeses, whisking until melted and smooth.

Step 4: Combine Pasta and Sauce

Add cooked bowtie pasta to the skillet, tossing gently to coat in the Alfredo. Use reserved pasta water a tablespoon at a time to loosen sauce if needed.

Step 5: Add Chicken and Serve

Top pasta with sliced Cajun chicken. Sprinkle with Italian seasoning and extra Parmesan if desired. Serve hot and enjoy that cheesy, spicy goodness!

How to Serve and Store This Cheesy Garlic Cajun Chicken Bowtie Pasta

For best presentation, plate the bowtie pasta first, ladle extra Alfredo sauce over the top, then arrange the sliced Cajun chicken alongside or on top. Garnish with freshly chopped parsley or a dusting of paprika for color.

Leftovers can be stored in an airtight container in the refrigerator for up to 3 days. Reheat gently on the stove with a splash of milk or cream to loosen the sauce. Freezing isn’t recommended, as the cream-based sauce may separate when thawed.

Frequently Asked Questions

How spicy is this dish?

The heat level depends on your Cajun seasoning. For less spice, choose a mild blend or reduce the amount used.

Can I use pre-cooked chicken?

Yes, just reheat the chicken in the skillet before adding it to the pasta. But fresh-seared chicken offers the best flavor.

Can I substitute the pasta?

Absolutely! Penne, rotini, or fettuccine work well too—just be sure it holds sauce nicely.

What’s the best cheese substitute for Parmesan?

Grana Padano or Pecorino Romano are great alternatives with similar sharp, salty flavors.

Is this Alfredo sauce homemade?

Yes, and it’s very easy to make! The result is richer and more flavorful than store-bought.

How can I make this dish healthier?

Use half-and-half instead of heavy cream, reduce cheese, and swap in whole wheat pasta.

Want More Pasta Ideas with a Kick?

If this Cajun chicken pasta hits the spot, you might love these other flavor-packed meals:

For even more recipe inspiration, check out my daily dishes on Pinterest: Life With Olivia

Save This Recipe for Later

📌 Save this recipe to your Pinterest dinner board so you can come back to it any time.

And let me know in the comments how yours turned out. Did you go extra cheesy? Did you add shrimp or veggies?

I love hearing how others bring their own twist to this recipe. Questions are always welcome too—let’s help each other cook with flavor and fun!

Cheesy Garlic Cajun Chicken Bowtie Pasta in Alfredo Sauce

Author: Olivia McKenney
Total Time: 30 minutes

Yield: 4 servings

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Description

This Cheesy Garlic Cajun Chicken Bowtie Pasta in Alfredo Sauce combines juicy Cajun-spiced chicken with creamy homemade Alfredo tossed in bowtie pasta. Bold, comforting, and perfect for any dinner table.