Name: Creamy Cajun Chicken Fettuccine with Garlic Mozzarella Cheese Sauce
Prep time: 10 min
Cook time: 20 min
Total time: 30 min
Cuisine: Cajun-American
Ingredients: 2 large chicken breasts; 2 tablespoons Cajun seasoning; 10 oz fettuccine pasta; 4 cloves garlic, minced; 1 ½ cups heavy cream; 1 ½ cups fresh mozzarella cheese, shredded; 2 tablespoons butter; 1 tablespoon olive oil; 2 tablespoons chopped parsley; ½ teaspoon salt; ¼ teaspoon black pepper

If you’re craving something bold, creamy, and impossibly satisfying, this Creamy Cajun Chicken Fettuccine with Garlic Mozzarella Cheese Sauce is for you. Imagine perfectly seasoned Cajun-spiced chicken, pan-seared to juicy perfection, sliced and served atop a bed of fettuccine smothered in a rich, cheesy garlic mozzarella sauce. This dish balances the heat of Cajun spices with the comforting creaminess of the sauce, creating an unforgettable flavor experience.

Perfect for a cozy night in or to impress dinner guests, this pasta delivers on both comfort and elegance. The textures are spot-on—tender pasta, gooey mozzarella, and crisp-edged chicken—all soaking in that golden, garlicky sauce. It’s hearty without being heavy, and spicy without overwhelming the creamy base. Let’s dive into what you’ll need and how to get it just right.

Preparation Phase & Tools to Use

To make the Creamy Cajun Chicken Fettuccine a breeze, having the right tools on hand is key:

Cast Iron Skillet or Heavy-Bottomed Pan — Perfect for achieving that golden crust on your chicken without burning the seasoning.
Large Pot — For boiling your fettuccine noodles until al dente.
Tongs — Useful for flipping the chicken and tossing the pasta evenly with sauce.

Microplane or Garlic Press — Essential for getting that fresh garlic into the sauce with max flavor and zero chunks.
Cheese Grater — Grating fresh mozzarella ensures a smooth melt and richer sauce compared to pre-shredded cheese.
Whisk — Helps emulsify the sauce, creating that smooth and creamy consistency.

Having these tools ready will save you time, reduce stress, and give you a professional-quality finish.

Ingredients for the Creamy Cajun Chicken Fettuccine

Chicken Breasts — The base protein, seasoned with Cajun spices for a punch of flavor and seared for a perfect crust.
Cajun Seasoning — Provides the bold, smoky, and slightly spicy flavor profile that defines this dish.

Fettuccine Pasta — Wide and flat noodles that hold onto the creamy sauce beautifully.
Fresh Garlic — Adds depth and aroma to the cheese sauce.
Heavy Cream — Creates the rich, velvety base for the sauce.

Fresh Mozzarella — Melts into the sauce, making it luxuriously gooey and cheesy.
Butter — Adds richness and helps build the base for the sauce.
Olive Oil — Used to cook the chicken and infuse it with flavor.

Chopped Parsley — A fresh garnish that cuts through the richness and adds color.
Salt & Black Pepper — To enhance and balance all the flavors.

How To Make the Creamy Cajun Chicken Fettuccine

Step 1: Prep and Season the Chicken

Pat the chicken breasts dry, then generously coat both sides with Cajun seasoning. Let them sit at room temperature while you prepare the other components.

Step 2: Sear the Chicken

In a hot skillet with olive oil, sear the chicken for about 6–7 minutes per side, until deeply golden and cooked through. Set aside to rest before slicing.

Step 3: Cook the Fettuccine

Boil a large pot of salted water and cook the fettuccine until al dente. Reserve 1/2 cup of pasta water before draining.

Step 4: Make the Garlic Mozzarella Sauce

In the same skillet, melt butter and sauté the minced garlic until fragrant. Pour in the heavy cream and whisk to combine. Slowly add the shredded mozzarella, stirring constantly until fully melted and silky. Use reserved pasta water to loosen the sauce if needed.

Step 5: Combine and Toss

Add the drained fettuccine into the skillet and toss gently in the sauce to coat. Slice the chicken and layer it over the top.

Step 6: Garnish and Serve

Sprinkle with chopped parsley and a touch of black pepper. Serve immediately while the sauce is gooey and warm.

Best Way to Serve and Store Creamy Cajun Chicken Fettuccine

This dish is best served fresh and piping hot, right after tossing the fettuccine with the cheese sauce. For a little extra indulgence, garnish with more mozzarella and broil briefly for a bubbly golden top.

To store leftovers, let the pasta cool completely, then transfer to an airtight container. It will keep well in the fridge for up to 3 days. Reheat gently on the stovetop or microwave, adding a splash of cream or milk to revive the sauce’s creaminess.

Frequently Asked Questions

Can I use a different pasta shape?

Absolutely! While fettuccine holds sauce well, penne, rigatoni, or linguine also work beautifully.

How spicy is this dish?

It has a mild to medium heat level, depending on your Cajun seasoning. For more kick, add a pinch of cayenne.

Can I make it ahead?

You can cook the chicken and make the sauce ahead of time, but it’s best to cook the pasta and combine everything fresh for optimal texture.

Can I use pre-shredded mozzarella?

You can, but fresh mozzarella melts creamier and gives the sauce a better texture.

Is this dish gluten-free?

Not by default, but you can substitute gluten-free pasta and check that your Cajun seasoning is gluten-free.

What protein can I use instead of chicken?

Shrimp, sliced sausage, or even tofu are great substitutes that still pair beautifully with the sauce.

Want More Chicken Pasta Ideas?

If you love this creamy Cajun chicken fettuccine, you’ll probably enjoy these other reader favorites:

Creamy Garlic Butter Chicken Rotini in Parmesan Sauce

Cheesy Garlic Chicken and Broccoli Pasta

For even more daily comfort food creations and visual inspo, follow my recipe board on Pinterest: Life With Olivia.

Save This Recipe for Later

📌 Save this recipe to your Pinterest dinner board so you can come back to it any time.

And let me know in the comments how yours turned out. Did you go heavy on the cheese? Add a pinch of red pepper flakes? Try it with shrimp instead?

I love hearing how others make these recipes their own. Questions are welcome too—let’s help each other cook smarter and tastier.

Creamy Cajun Chicken Fettuccine with Garlic Mozzarella Cheese Sauce

Author: Olivia McKenney

Total Time: 30 minutes
Yield: 4 servings

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Description

Creamy Cajun Chicken Fettuccine with Garlic Mozzarella Cheese Sauce is a rich and satisfying pasta dish featuring Cajun-spiced seared chicken served over fettuccine tossed in a luscious garlic mozzarella cream sauce. It’s bold, comforting, and perfect for cozy dinners or special occasions.

Instructions

1. Pat the chicken breasts dry and season generously with Cajun seasoning. Let sit at room temperature for 10 minutes.

2. In a skillet, heat olive oil over medium-high heat. Sear chicken for 6–7 minutes per side until golden and cooked through. Remove and rest before slicing.

3. In a large pot of salted water, cook fettuccine until al dente. Reserve ½ cup pasta water, then drain.

4. In the skillet, melt butter. Add garlic and sauté for 1 minute until fragrant.

5. Pour in heavy cream and whisk to combine. Slowly stir in shredded mozzarella until fully melted and smooth.

6. Add reserved pasta water to thin the sauce if needed.

7. Toss cooked fettuccine in the sauce until fully coated.

8. Slice chicken and place on top of pasta.

9. Garnish with chopped parsley and black pepper. Serve warm.