Cajun Beef Spaghetti in Creamy Three-Cheese Parmesan Sauce

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Nothing satisfies a savory craving like a heaping plate of pasta drenched in creamy, cheesy goodness. This Cajun Beef Spaghetti in Creamy Three-Cheese Parmesan Sauce is where comfort food meets a spicy Southern twist. With its bold Cajun seasoning, perfectly browned ground beef, and an indulgent trio of cheeses, this dish transforms ordinary spaghetti into an unforgettable dinner.

Perfect for a weeknight family meal or to impress guests at a dinner party, this spaghetti recipe has layers of flavor. The heat from Cajun spices is mellowed by the richness of heavy cream and the nuttiness of Parmesan, mozzarella, and provolone. Topped with fresh parsley and served bubbling hot, it hits every note of comfort and excitement in one bite.

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Preparation Phase & Tools to Use

To bring out the best in this recipe, having the right tools makes the process smoother and more enjoyable:

• Large Skillet or Cast Iron Pan: Ideal for browning the beef evenly and simmering the sauce to perfection without scorching.
• Heavy-Bottomed Pot: For boiling spaghetti. It ensures consistent heat and prevents sticking.
• Fine Mesh Strainer or Colander: Crucial for draining pasta efficiently without overcooking it.
• Wooden Spoon or Silicone Spatula: Helps with even mixing of the cheesy sauce into the beef without breaking the pasta.
• Grater: Freshly grated cheeses melt better and offer deeper flavor. A good grater is key for Parmesan and provolone.

Each tool plays a specific role in crafting a dish that’s as seamless in texture as it is bold in taste. Having your tools prepped ensures your focus stays on flavor.

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Ingredients for the Cajun Beef Spaghetti in Creamy Three-Cheese Parmesan Sauce

• Ground Beef: The star of the dish. Rich, savory, and perfect for absorbing Cajun spices.
• Spaghetti: Traditional and sturdy, this pasta holds the creamy sauce beautifully.
• Heavy Cream: The base for that luscious, velvety texture.
• Parmesan Cheese: Adds nutty sharpness and depth.
• Mozzarella Cheese: Offers a gooey, stretchy bite and creamy balance.
• Provolone Cheese: Brings a smoky richness that pairs beautifully with Cajun flavor.
• Cajun Seasoning: The bold, zesty heart of the recipe.
• Garlic: Freshly minced for that aromatic foundation.
• Onion: Adds sweet, caramelized complexity.
• Olive Oil or Butter: Needed to sauté the aromatics and brown the beef.
• Salt & Black Pepper: To enhance and balance the flavors.
• Fresh Parsley: For garnish and a pop of freshness.

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How To Make the Cajun Beef Spaghetti in Creamy Three-Cheese Parmesan Sauce

Step 1: Sauté the Aromatics

Heat olive oil or butter in your skillet. Add chopped onion and garlic. Sauté until softened and fragrant—this forms the base of flavor.

Step 2: Brown the Beef

Add the ground beef to the skillet. Cook until fully browned, breaking it apart with a spoon. Drain excess fat, if needed.

Step 3: Spice It Up

Sprinkle in Cajun seasoning, salt, and black pepper. Stir well so the beef is fully coated and infused with that Southern heat.

Step 4: Add the Cream and Simmer

Pour in the heavy cream and let it come to a light simmer. Lower the heat and allow the sauce to thicken slightly.

Step 5: Stir in the Cheeses

Gradually add Parmesan, mozzarella, and provolone, stirring constantly until melted and smooth.

Step 6: Boil the Spaghetti

In a separate pot, cook the spaghetti to al dente. Drain and toss lightly with a touch of oil or butter to prevent sticking.

Step 7: Combine and Serve

Add the cooked spaghetti into the creamy beef sauce. Mix until every strand is coated. Serve hot, garnished with parsley.

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How to Serve and Store This Cheesy Cajun Pasta Dish

Serve this dish piping hot in shallow pasta bowls, allowing the cheese and creamy sauce to stay warm and velvety. A side of garlic bread or toasted baguette makes the perfect accompaniment. You can even top it with an extra sprinkle of Parmesan or a drizzle of hot sauce for a personalized kick.

To store, let leftovers cool completely before transferring to an airtight container. It keeps well in the refrigerator for up to 4 days. Reheat gently on the stove or in the microwave, adding a splash of milk or cream to loosen the sauce.

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Frequently Asked Questions

Can I use a different type of pasta?

Absolutely! While spaghetti works beautifully, fettuccine, penne, or even rotini can hold the sauce well.

Is this recipe spicy?

The heat depends on your Cajun seasoning. For milder heat, use a low-sodium or mild blend. Want more fire? Add crushed red pepper flakes.

Can I make it ahead of time?

Yes! Prepare the sauce and pasta separately, then mix and reheat when ready to serve. It actually deepens in flavor overnight.

Can I freeze this dish?

Cream-based sauces can separate slightly when frozen. For best results, freeze the beef-Cajun sauce only, then make fresh pasta when serving.

What proteins can I use besides beef?

Ground turkey, sausage, or even shredded rotisserie chicken work well. Just adjust seasonings based on the meat’s flavor.

How do I keep the sauce from clumping?

Stir constantly when adding cheese and lower the heat. Freshly grated cheese melts smoother than pre-shredded.

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Want More Pasta Ideas with a Kick?

If this cheesy Cajun spaghetti hits the spot, you’ll definitely enjoy these other bold and hearty meals:

• One Skillet Spicy Garlic Butter Parmesan Steak Pasta for another rich, meaty pasta option.
• Cheesy Garlic Chicken and Broccoli Pasta when you want something creamy with a veggie boost.
• One Skillet Spicy Honey BBQ Sausage Pasta if you’re craving sweet and smoky layers.
• Creamy Garlic Butter Chicken Rotini in Parmesan Sauce for a cozy twist on a classic.
• Beef and Rotini in Garlic Parmesan Sauce if you’re looking for a creamy weeknight crowd-pleaser.

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Save This Recipe for Later

📌 Save this recipe to your Pinterest dinner board so you can come back to it any time.

And let me know in the comments how yours turned out. Did you make it spicier? Try a different cheese combo? Maybe even add shrimp?

I love hearing how others make these recipes their own. Questions are welcome too—let’s help each other cook smarter.

For more daily meal inspiration, check out my boards on Pinterest at Life With Olivia.

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